Opportunity Information: Apply for PAR 21 251
The Emerging Global Leader Award (K43 Independent Clinical Trial Required) is a National Institutes of Health (NIH) discretionary grant opportunity designed to support the career development of promising early-career investigators working in global health and related research areas. This specific announcement is a reissue of the NIH Emerging Global Leader Program (K43), updated to align with NIH clinical trials policy, which means the funding opportunity is structured to follow NIH rules and definitions about what counts as a clinical trial and what applicants must include when a clinical trial is proposed. As indicated by the title, this version of the K43 is intended for applicants whose proposed research will include an independent clinical trial, so applicants should be prepared for the additional application components, oversight expectations, and reporting requirements that typically accompany clinical trial activity under NIH policy.
Eligibility is oriented toward non-U.S. organizations. The announcement explicitly states that non-domestic (non-U.S.) entities, described as foreign organizations, are eligible to apply. At the same time, it clarifies an important restriction: non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply as applicants. In other words, a foreign organization can apply directly, but an overseas branch or non-U.S. component of a U.S.-based institution cannot be the applicant organization for this opportunity. The opportunity does allow foreign components as defined in the NIH Grants Policy Statement, meaning a U.S. applicant (in other contexts) could include a foreign component in a project, but for this specific listing the primary applicant eligibility highlighted is for non-U.S. entities while excluding non-U.S. components of U.S. organizations as the applicant.
Administratively, the program is offered by the NIH and is categorized as a grant mechanism under a discretionary opportunity category. The funding opportunity number is PAR-21-251, and the funding opportunity title is Emerging Global Leader Award (K43 Independent Clinical Trial Required). The listing references multiple CFDA numbers (93.113, 93.121, 93.172, 93.242, 93.313, 93.398, 93.853, 93.989), which indicates it can be supported through several NIH funding streams or institutes/centers that align with those assistance listings. The original closing date shown is 2023-12-11, and the record creation date is 2021-09-08. The summary information provided does not specify an award ceiling or the expected number of awards, so applicants would need to consult the full funding opportunity announcement text for budget limits, allowable costs, project period details, review criteria, and institute-specific participation.
In practical terms, this opportunity is best understood as a mentored-to-independence style career development award focused on building research leadership capacity in global settings, with the added requirement that the proposed work includes an independent clinical trial. Applicants considering this mechanism should plan for a proposal that clearly justifies the clinical trial, demonstrates the investigator's ability and training plan to lead it, and shows that the applicant organization has the infrastructure and ethical/regulatory capacity to conduct and monitor clinical research in line with NIH expectations.Apply for PAR 21 251
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Emerging Global Leader Award (K43 Independent Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.172, 93.242, 93.313, 93.398, 93.853, 93.989.
- This funding opportunity was created on 2021-09-08.
- Applicants must submit their applications by 2023-12-11. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others.
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Frequently Asked Questions (FAQs)
What is the Emerging Global Leader Award (K43 Independent Clinical Trial Required)?
The Emerging Global Leader Award (K43 Independent Clinical Trial Required) is a National Institutes of Health (NIH) discretionary grant opportunity intended to support the career development of promising early-career investigators working in global health and related research areas. This version of the K43 is specifically structured for applicants whose proposed research will include an independent clinical trial.
What does "Independent Clinical Trial Required" mean for this funding opportunity?
It means the applicant's proposed research is expected to include an independent clinical trial. Because a clinical trial is part of the proposed work, the application should account for the additional NIH policy-driven expectations that typically come with clinical trial activity, including added application components, oversight expectations, and reporting requirements.
Is this funding opportunity aligned with NIH clinical trials policy?
Yes. This announcement is described as a reissue of the NIH Emerging Global Leader Program (K43) that was updated to align with NIH clinical trials policy. The structure of the opportunity is designed to follow NIH rules and definitions about what counts as a clinical trial and what must be included when a clinical trial is proposed.
Who is the intended audience for this award?
The opportunity is intended for promising early-career investigators in global health and related research areas, particularly those seeking a career development mechanism that supports research leadership capacity in global settings while leading an independent clinical trial.
Are non-U.S. organizations eligible to apply?
Yes. The announcement explicitly states that non-domestic (non-U.S.) entities, described as foreign organizations, are eligible to apply.
Can a non-U.S. component of a U.S. organization apply as the applicant?
No. The announcement clarifies that non-domestic (non-U.S.) components of U.S. organizations are not eligible to apply as applicant organizations for this opportunity. A foreign organization may apply directly, but an overseas branch or component of a U.S.-based institution cannot be the applicant entity.
Does the opportunity allow foreign components?
Yes. The listing notes that foreign components (as defined in the NIH Grants Policy Statement) are allowed. However, the eligibility restriction described in the summary specifically addresses who may be the applicant organization for this opportunity.
Which agency offers this program?
The program is offered by the National Institutes of Health (NIH).
What is the funding opportunity number (FOA number)?
The funding opportunity number is PAR-21-251.
What is the official title of the funding opportunity?
The official title is "Emerging Global Leader Award (K43 Independent Clinical Trial Required)."
What type of funding mechanism is this?
It is categorized as a grant mechanism under a discretionary opportunity category, and it is described as a career development award that supports progression toward research leadership and independence.
Is this award described as a mentored-to-independence style career development program?
Yes. The summary describes it in practical terms as a mentored-to-independence style career development award focused on building research leadership capacity in global settings, with the added requirement of an independent clinical trial.
What clinical trial-related expectations should applicants plan for?
Applicants should plan for the additional application components, oversight expectations, and reporting requirements that typically accompany clinical trial activity under NIH policy. The summary emphasizes being prepared to meet NIH expectations for conducting and monitoring clinical research.
What should a strong application emphasize, based on the summary?
Based on the information provided, applicants should be prepared to: clearly justify the clinical trial; demonstrate the investigator's ability to lead the trial; include a training/career development plan appropriate for leading the work; and show that the applicant organization has the infrastructure and ethical/regulatory capacity to conduct and monitor clinical research consistent with NIH expectations.
Does the summary specify an award ceiling (maximum award amount)?
No. The summary information provided does not specify an award ceiling.
Does the summary specify the expected number of awards?
No. The summary information provided does not specify the expected number of awards.
Where should applicants look for budget limits, allowable costs, project period details, review criteria, and institute-specific participation?
The summary indicates that applicants would need to consult the full funding opportunity announcement text for budget limits, allowable costs, project period details, review criteria, and institute-specific participation.
What CFDA numbers are associated with this opportunity?
The listing references multiple CFDA numbers: 93.113, 93.121, 93.172, 93.242, 93.313, 93.398, 93.853, and 93.989. This suggests the opportunity can be supported through several NIH funding streams or institutes/centers aligned with those assistance listings.
What is the original closing date listed for this opportunity?
The original closing date shown is 2023-12-11.
What is the record creation date listed for this opportunity?
The record creation date shown is 2021-09-08.
What is the main purpose of this K43 version in practical terms?
In practical terms, it is designed to build research leadership capacity in global settings for early-career investigators, while requiring that the proposed research includes an independent clinical trial conducted under NIH clinical trials policy expectations.
Browse more opportunities from the same category: Education, Environment, Health
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 21 251) also looked into and applied for these:
| Funding Opportunity |
|---|
| Virtual Consortium for Translational/Transdisciplinary Environmental Research (ViCTER) (R01 Clinical Trial Optional) Apply for RFA ES 21 007 Funding Number: RFA ES 21 007 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $475,000 |
| Measures and Methods to Advance Research on Minority Health and Health Disparities-Related Constructs (R01 Clinical Trial Not Allowed) Apply for PAR 22 072 Funding Number: PAR 22 072 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $500,000 |
| Emergency Award: Rapid Acceleration of Diagnostics Tribal Data Repository (RADx TDR) (U24 Clinical Trial Not Allowed) Apply for RFA OD 22 011 Funding Number: RFA OD 22 011 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $2,000,000 |
| CCRP Initiative: Countermeasures Against Chemical Threats (CounterACT) Therapeutics Discovery and Early-Stage Development (UG3/UH3 Clinical Trial Not Allowed) Apply for PAR 22 209 Funding Number: PAR 22 209 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $350,000 |
| Multi-Omics for Health and Disease - Disease Study Sites (U01 Clinical Trial Optional) Apply for RFA HG 22 008 Funding Number: RFA HG 22 008 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $500,000 |
| Multi-Omics for Health and Disease - Data Analysis and Coordination Center (U01 Clinical Trial Not Allowed) Apply for RFA HG 22 010 Funding Number: RFA HG 22 010 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $950,000 |
| Multi-Omics for Health and Disease - 'Omics Production Centers (U01 Clinical Trial Not Allowed) Apply for RFA HG 22 009 Funding Number: RFA HG 22 009 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $2,700,000 |
| The Intersection of Sex and Gender Influences on Health and Disease (R01 Clinical Trial Optional) Apply for RFA OD 22 028 Funding Number: RFA OD 22 028 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $350,000 |
| Implementation Research on Noncommunicable Disease Risk Factors among Low- and Middle-Income Country and Tribal Populations Living in City Environments (R01 Clinical Trial Optional) Apply for PAR 23 042 Funding Number: PAR 23 042 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Genomic Community Resources (U24 Clinical Trial Not Allowed) Apply for PAR 23 085 Funding Number: PAR 23 085 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Biomedical Data Repository (U24 - Clinical Trials Not Allowed) Apply for PAR 23 079 Funding Number: PAR 23 079 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Biomedical Knowledgebase (U24 - Clinical Trials Not Allowed) Apply for PAR 23 078 Funding Number: PAR 23 078 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed) Apply for RFA ES 23 004 Funding Number: RFA ES 23 004 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Medical Scientist Partnership Program (FM1 Clinical Trial Not Allowed) Apply for PAR 23 109 Funding Number: PAR 23 109 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Translational Exploratory/Developmental Research Projects (R21 Clinical Trial Not Allowed) Apply for PAR 23 139 Funding Number: PAR 23 139 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $275,000 |
| Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional) Apply for RFA ES 23 001 Funding Number: RFA ES 23 001 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $2,000,000 |
| STrengthening Research Opportunities for NIH Grants (STRONG): Structured Institutional Needs Assessment and Action Plan Development for Resource Limited Institutions (RLIs) (UC2 - Clinical Trial Not Allowed) Apply for PAR 23 144 Funding Number: PAR 23 144 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $250,000 |
| Tobacco Regulatory Science (R01 Clinical Trial Optional) Apply for RFA OD 23 017 Funding Number: RFA OD 23 017 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $500,000 |
| Center for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01 Clinical Trial Not Allowed) Apply for PAR 23 184 Funding Number: PAR 23 184 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Time-Sensitive Research Opportunities in Environmental Health Sciences (R21 Clinical Trial Not Allowed) Apply for RFA ES 23 011 Funding Number: RFA ES 23 011 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $275,000 |
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