Opportunity Information: Apply for 7200AA25RFA00001
The New Partners Initiative Translational HIV Research for Innovative Vaccines Ecosystem (NPI THRIVE) is a USAID funding opportunity designed to speed up progress toward a safe, globally effective HIV vaccine. USAID is soliciting applications for cooperative agreements, which typically means the agency expects to have substantial involvement during implementation (for example, providing ongoing technical input, coordination, and oversight as the program advances). The activity is explicitly framed under USAID's New Partnerships Initiative (NPI), so the emphasis is on bringing in new, nontraditional, and especially local partners, and on supporting locally led approaches rather than relying only on the usual set of large, established implementers.
At the center of NPI THRIVE is the idea of building and strengthening a collaborative translational research ecosystem for HIV vaccine development that is led by scientists and institutions based in African countries with high HIV burden. The model is not isolated or regionally siloed; instead, USAID is looking for close partnerships between African-led teams and leading scientific institutions from other regions. The intention is to make vaccine research and development more inclusive and more grounded in the settings most affected by HIV, while still leveraging global scientific expertise. In practice, this kind of ecosystem approach often implies shared governance, stronger regional research infrastructure, and sustained collaboration that can move promising concepts along the pipeline from early research into human testing.
The program is structured around two complementary objectives: one focused on clinical research and one focused on preclinical research. While the notice does not provide deep technical detail in the summary text, the division signals that USAID wants to support both ends of the translational pathway: preclinical work that can generate and refine vaccine candidates, and clinical research capacity and activities that can evaluate candidates in humans. USAID indicates it intends to make at least two awards, with at least one award aligned to each objective, and final selection will be based on the merit review criteria in the Notice of Funding Opportunity (NOFO), along with a risk assessment. That combination means applicants should be prepared not only to make a strong technical case, but also to demonstrate solid operational, financial, and compliance capacity to manage a large, high-stakes research partnership.
Eligibility is described as not restricted in the narrative, though the opportunity listing also notes an eligible applicant category as nonprofits with 501(c)(3) status (other than institutions of higher education). Applicants should rely on the full NOFO language for controlling eligibility rules and documentation requirements, since the narrative and the structured fields do not always capture nuances like whether international organizations, universities, or consortia may apply as prime recipients or subrecipients. The opportunity is administered by the U.S. Agency for International Development under CFDA 98.001 and is categorized under health.
Key administrative details from the posting include the funding opportunity number 7200AA25RFA00001, an original application closing date of January 28, 2025, and an award ceiling listed at $98,500,000. USAID states the NOFO is posted on Grants.gov and may be amended, so applicants are expected to monitor the listing for updates and ensure they are working from the complete, most current version of the announcement. For access or registration problems, the notice directs applicants to the Grants.gov Helpdesk at 1-800-518-4726 or support@grants.gov.Apply for 7200AA25RFA00001
- The Agency for International Development in the health sector is offering a public funding opportunity titled "New Partners Initiative Translational HIV Research for Innovative Vaccines Ecosystem (NPI THRIVE)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 98.001.
- This funding opportunity was created on 2024-12-18.
- Applicants must submit their applications by 2025-01-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $98,500,000.00 in funding.
- Eligible applicants include: Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education.
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