Opportunity Information: Apply for RFA DD 16 001
The Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE): Study to Explore Early Development (SEED) 3 grant opportunity (RFA DD 16 001) is a CDC cooperative agreement designed to strengthen and extend national capacity to study autism spectrum disorder (ASD) and other developmental disabilities through large-scale, multi-site epidemiologic research. The core purpose is to continue the work of the CADDRE Network by carrying out SEED Phase 3, a major case-control study focused on identifying genetic and environmental risk factors, as well as protective factors, associated with autism. SEED relies on multiple sources to identify and confirm both case groups and comparison groups, which helps improve the completeness and validity of participant ascertainment. Phase 3 continues the foundational design used in SEED 1 and SEED 2, but it updates operations with improved recruitment approaches and a streamlined data collection package in some areas to reduce burden while still supporting rigorous analysis.
The FOA is organized into three components. Component A is the main research and field implementation effort: it supports applicants in continuing the CADDRE epidemiological infrastructure and executing SEED Phase 3 using the established case-control framework. This includes identifying eligible children and families, confirming case status using consistent methods across sites, enrolling an appropriate comparison group, and collecting standardized data needed to evaluate exposures and outcomes. The emphasis is on maintaining a high-quality, coordinated network that can produce comparable data across locations, enabling pooled analyses and more reliable conclusions about ASD etiology and related developmental outcomes.
Component B focuses on laboratory and biospecimen infrastructure through the SEED Central Laboratory and Biosample Repository (CLBR). Its purpose is twofold: first, to maintain and store the biosample collections already gathered during SEED Phases 1 and 2, and second, to support the collection, processing, and long-term storage of biosamples collected during SEED Phase 3. This component is intended to preserve the scientific value of prior investments and ensure that new biospecimens are handled consistently, enabling future genetic, biomarker, and exposure-related analyses. Applicants may apply for Component B only if they are applying for Component A, meaning biospecimen repository activities are structured as an extension of the broader SEED Phase 3 field research effort.
Component C is a separate but related planning and feasibility activity aimed at the long-term value of SEED. Under this component, awardees develop and implement a short protocol and feasibility assessment to evaluate conducting a follow-up study of children who participated in SEED 1 and completed its data collection. Rather than launching a full follow-up study immediately, the goal is to test practical elements such as participant re-contact, willingness to participate, and the logistics of collecting updated outcome information. This helps determine whether a larger longitudinal follow-up is realistic and how it should be designed to maximize scientific usefulness.
The FOA includes special eligibility and completeness requirements that applicants must satisfy in Appendix A; failure to provide these materials makes an application non-responsive and it will not be reviewed. Specifically, applicants must submit (1) 2014 vital statistics data showing the number of births across all jurisdictions included in the proposed catchment area (state, territories, counties, or other relevant divisions), along with a map of that catchment area; (2) data describing the racial, ethnic, and socioeconomic characteristics of the catchment area and proposed study population, drawing from credible official sources such as government reports or published datasets; (3) documentation showing negotiation with the state vital records authority regarding access terms for birth certificate data, such as a letter on official letterhead, an MOU, or similar formal documentation; and (4) documentation showing negotiation and established partnerships with ASD and developmental disability ascertainment sources, which may include clinics, health systems, schools, or state disability programs, again supported by formal letters or agreements. Applicants must clearly label each appendix document to indicate which of the four criteria it addresses.
Administratively, this is a discretionary health funding opportunity using a cooperative agreement mechanism, meaning CDC expects substantial involvement and collaboration during project execution rather than a hands-off grant relationship. Eligibility is broad and includes various levels of government, public and private higher education institutions, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (including small businesses), tribal governments and tribal organizations, independent school districts, and other unrestricted entities. The CDC office listed is Centers for Disease Control and Prevention - ERA. The opportunity originally closed on February 11, 2016, with an expected seven awards and an award ceiling of $800,000. The overall structure signals CDCs intent to sustain a coordinated, multi-site research platform that can produce high-quality epidemiologic and biospecimen resources for understanding autism risk and resilience, while also laying groundwork for potential longer-term follow-up of earlier SEED participants.Apply for RFA DD 16 001
- The Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE): Study to Explore Early Development (SEED) 3" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.073.
- This funding opportunity was created on 2015-12-03.
- Applicants must submit their applications by 2016-02-11. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $800,000.00 in funding.
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others, Unrestricted.
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