Opportunity Information: Apply for PAR 22 213
The NIH funding opportunity PAR 22-213, titled "Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional)," supports large, coordinated aging research programs built around a single, clearly defined scientific question or theme relevant to aging. The intent is to fund projects that are too large or too interdependent to be handled well as a set of separate grants, and that genuinely require multiple integrated components working together. Applications are expected to describe a complex, multi-part research effort where the pieces are scientifically linked and collectively designed to answer a central question in aging research, rather than a loose collection of independent studies.
This opportunity uses the U19 mechanism, which is a cooperative agreement. In practice, that means the NIH is not simply providing funds and stepping back; instead, the funded team should anticipate ongoing scientific or programmatic involvement from the NIH during the life of the award. The FOA is also labeled "Clinical Trial Optional," meaning applicants may include a clinical trial component if it is appropriate for the overall integrated project, but a clinical trial is not required. The emphasis is on tightly connected, multidisciplinary work that benefits from coordination, shared resources, and an overall management structure that keeps the components aligned.
Projects funded under this FOA will typically involve multidisciplinary investigator teams, either within a single institution or across a consortium of institutions. The structure is meant for research that needs multiple interacting parts, such as different projects, cores, shared methods, coordinated data approaches, or other components that depend on each other to succeed. Reviewers will generally expect the application to make a strong case that integration is essential, explaining how the different parts inform one another, how coordination will be handled, and how the overall design improves scientific payoff compared with smaller or stand-alone studies.
Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including both 501(c)(3) and non-501(c)(3) nonprofits) other than institutions of higher education; for-profit organizations other than small businesses; small businesses; public housing authorities/Indian housing authorities; and Native American tribal governments (federally recognized) as well as Native American tribal organizations that are not federally recognized tribal governments. The FOA also explicitly highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal government agencies, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions.
At the same time, the FOA places clear limits on foreign involvement. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as the applicant organization. In addition, non-domestic components of U.S. organizations are not eligible to apply. However, foreign components are allowed as defined in the NIH Grants Policy Statement, which generally means a U.S. applicant can include certain types of foreign collaboration or subcomponents when they are well-justified and meet NIH policy requirements.
From an administrative standpoint, this is a discretionary funding opportunity under the health category, with assistance listing CFDA number 93.866, and it is administered by the National Institutes of Health. The FOA was created on 2022-07-07, and the listed original closing date is 2025-09-25. The source information provided does not specify an award ceiling or the expected number of awards, which typically means applicants should rely on the full FOA text and NIH guidance for budgeting expectations and any institute- or program-specific constraints.
Overall, the opportunity is best suited for applicants who can propose a cohesive, high-impact aging research program that demands strong integration across multiple research components, supported by a management and collaboration plan capable of handling the complexity of a cooperative agreement. The most competitive proposals will usually be the ones that make the integration feel necessary rather than optional, show how the team and infrastructure are set up to operate as one coordinated effort, and demonstrate a clear pathway to advancing aging-related science through the combined contributions of all components.Apply for PAR 22 213
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
- This funding opportunity was created on 2022-07-07.
- Applicants must submit their applications by 2025-09-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
FAQs: NIH PAR-22-213 - Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional)
What is NIH PAR-22-213?
PAR-22-213 is a National Institutes of Health (NIH) funding opportunity titled "Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional)." It supports large, coordinated aging research programs that are organized around a single, clearly defined scientific question or theme relevant to aging.
What is the main purpose of this funding opportunity?
The purpose is to fund complex, integrated, multi-component aging research efforts that are too large or too interdependent to be handled effectively as separate, stand-alone grants. The program is designed for projects where multiple components must work together to answer a central aging research question.
What type of award mechanism does this opportunity use?
This opportunity uses the U19 mechanism, which is a cooperative agreement. That means NIH is expected to have ongoing scientific and/or programmatic involvement during the award, rather than functioning only as a funder.
What does "cooperative agreement" mean for applicants and awardees?
Because the mechanism is a cooperative agreement (U19), applicants should anticipate that NIH will play an active role during the life of the award. The expectation is that the funded team will interact with NIH in ways that reflect ongoing involvement, not just initial award and reporting.
Is a clinical trial required under this FOA?
No. The FOA is labeled "Clinical Trial Optional," meaning a clinical trial component may be included if it fits the overall integrated project, but it is not required.
If clinical trials are optional, when would including one make sense?
Including a clinical trial may make sense if it is appropriate to the integrated, multi-component program and helps answer the central scientific question in aging research. The key is that any clinical trial component should be tightly linked to the overall program rather than operating as an independent study.
What kinds of projects are a good fit for this U19 FOA?
This FOA is intended for projects that require multiple interacting parts such as several research projects, shared cores, shared methods, coordinated data approaches, and other interdependent components. The best fit is a cohesive program where the pieces are scientifically linked and collectively designed to answer one central question in aging research.
What does NIH mean by "complex, integrated, multi-component" in this context?
It refers to a research effort made up of multiple parts that depend on each other and are designed to work together. The FOA emphasizes that applications should not be a loose collection of independent studies; instead, the components should be intentionally integrated so that coordination improves the overall scientific payoff.
Do projects have to be multidisciplinary?
Projects funded under this FOA will typically involve multidisciplinary investigator teams. Teams may be based within a single institution or across a consortium of institutions, depending on what is needed to execute the integrated program.
Can an application come from a single institution, or does it have to be a consortium?
Either approach may be appropriate. The FOA indicates projects may involve teams within a single institution or across a consortium of institutions, as long as the structure supports the integrated, coordinated program needed to address the central aging research question.
What will reviewers generally expect to see regarding integration?
Reviewers will generally expect a strong case that integration is essential. Applications should explain how the components inform one another, why coordination is required, how the overall effort will be managed, and how the integrated design improves scientific impact compared to smaller or stand-alone studies.
What role do shared resources or cores play in this type of program?
The FOA highlights that the structure is meant for research benefiting from coordination and shared resources. Shared cores, common methods, and coordinated data approaches are examples of components that can help link projects and support an integrated scientific strategy.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofits (both 501(c)(3) and non-501(c)(3)) other than institutions of higher education; for-profit organizations other than small businesses; small businesses; public housing authorities/Indian housing authorities; and Native American tribal governments (federally recognized) as well as Native American tribal organizations that are not federally recognized tribal governments.
Are minority-serving institutions explicitly eligible?
Yes. The FOA explicitly highlights categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs) as eligible.
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly includes faith-based or community-based organizations among the highlighted eligible categories.
Are U.S. territories or possessions eligible to apply?
Yes. The FOA explicitly highlights U.S. territories or possessions as eligible.
Are federal government agencies eligible?
Yes. The FOA includes eligible federal government agencies among the highlighted eligible categories.
Can a foreign institution apply as the main applicant?
No. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as the applicant organization.
Can a non-domestic component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are not eligible to apply as the applicant organization.
Is any foreign involvement allowed at all?
Yes. While foreign institutions cannot be the applicant, foreign components are allowed as defined in the NIH Grants Policy Statement. In general terms, a U.S. applicant may include certain types of foreign collaboration or subcomponents when well-justified and consistent with NIH policy requirements.
What is the assistance listing (CFDA) number for this opportunity?
The assistance listing (CFDA) number provided is 93.866.
Which agency administers this funding opportunity?
This opportunity is administered by the National Institutes of Health (NIH).
What is the funding category and funding type described?
The opportunity is described as a discretionary funding opportunity under the health category.
When was this FOA created?
The FOA was created on 2022-07-07.
What is the listed original closing date?
The listed original closing date is 2025-09-25.
Does the provided information include an award ceiling?
No. The provided source information does not specify an award ceiling.
Does the provided information state how many awards NIH expects to make?
No. The provided source information does not specify the expected number of awards.
How should applicants think about budgeting if no award ceiling is listed here?
Because the provided information does not include an award ceiling or expected number of awards, applicants are typically expected to consult the full FOA text and NIH guidance for budgeting expectations and any institute- or program-specific constraints.
What makes an application more competitive under this FOA?
The most competitive proposals are typically those that make integration feel necessary rather than optional, show that the team and infrastructure can operate as one coordinated effort, and demonstrate a clear pathway to advancing aging-related science through the combined contributions of all components.
What is the core idea that should unify the application?
The application should be built around one clearly defined scientific question or theme relevant to aging. The multiple components should be scientifically linked and collectively designed to answer that central question.
What should applicants avoid when designing a multi-component program for this FOA?
Applicants should avoid proposing a loose collection of independent studies. The FOA emphasizes that the pieces should be intentionally connected and interdependent, with coordination and shared infrastructure used to strengthen the overall scientific payoff.
Browse more opportunities from the same category: Health
Next opportunity: Cancer Adoptive Cellular Therapy Network (Can-ACT) for Adult Cancers (UG3/UH3 Clinical Trial Required)
Previous opportunity: Bureau of Land Management New Mexico Plant Conservation and Restoration Management
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 22 213
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 22 213) also looked into and applied for these:
| Funding Opportunity |
|---|
| New Epidemiological Cohort Study among Asian Americans, Native Hawaiians, and Pacific Islanders (AsA-NHPI): Coordinating Center (U24 - Clinical Trial Not Allowed) Apply for RFA HL 23 016 Funding Number: RFA HL 23 016 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Novel Assays to Address Translational Gaps in Treatment Development (UG3/UH3 Clinical Trial Optional) Apply for PAR 22 169 Funding Number: PAR 22 169 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| More Monitoring of Cognitive Change, Continued (M3C3) (U2C Clinical Trial Optional) Apply for RFA AG 23 021 Funding Number: RFA AG 23 021 Agency: National Institutes of Health Category: Health Funding Amount: $4,800,000 |
| Epigenetic Mechanisms Regulating HIV CNS Latency and Neuropathogenesis Using Novel Single Cell Technologies (R21 Clinical Trial Not Allowed) Apply for RFA MH 22 281 Funding Number: RFA MH 22 281 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Epigenetic Mechanisms Regulating HIV CNS Latency and Neuropathogenesis Using Novel Single Cell Technologies (R01 Clinical Trial Not Allowed) Apply for RFA MH 22 280 Funding Number: RFA MH 22 280 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Data Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required) Apply for PAR 22 193 Funding Number: PAR 22 193 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required) Apply for PAR 22 192 Funding Number: PAR 22 192 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Single-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required) Apply for PAR 22 189 Funding Number: PAR 22 189 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required) Apply for RFA TR 22 029 Funding Number: RFA TR 22 029 Agency: National Institutes of Health Category: Health Funding Amount: $325,000 |
| Modern Equipment for Shared-use Biomedical Research Facilities: Advancing Research-Related Operations (R24 Clinical Trials Not Allowed) Apply for PAR 22 190 Funding Number: PAR 22 190 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Postdoctoral Research Associate Training (PRAT) Program (Fi2) Apply for PAR 22 191 Funding Number: PAR 22 191 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Institutional Research and Academic Career Development Awards (IRACDA) (K12 - Independent Clinical Trial Not Allowed) Apply for PAR 22 212 Funding Number: PAR 22 212 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Understanding Persistent Signs and Symptoms Attributed to Post-Treatment Lyme Disease (R01 Clinical Trial Not Allowed) Apply for RFA AI 22 046 Funding Number: RFA AI 22 046 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| Early Liver Transplantation Cohort Study for Alcohol-associated Liver Diseases (Collaborative R01 Clinical Trial Not Allowed) Apply for RFA AA 22 003 Funding Number: RFA AA 22 003 Agency: National Institutes of Health Category: Health Funding Amount: $350,000 |
| Functional Target Validation for Alzheimer's Disease-Related Dementias (ADRDs) (R61/R33 Clinical Trial Not Allowed) Apply for RFA NS 22 055 Funding Number: RFA NS 22 055 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition for the Continuation of Clinical Sites for the Undiagnosed Diseases Network (U01 Clinical Trial Not Allowed) Apply for RFA NS 23 004 Funding Number: RFA NS 23 004 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| NIMH Biobehavioral Research Awards for Innovative New Scientists (NIMH BRAINS) (R01 Clinical Trial Optional) Apply for RFA MH 22 185 Funding Number: RFA MH 22 185 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| Geroscience Course (R25 Independent Clinical Trial Not Allowed) Apply for PAR 22 214 Funding Number: PAR 22 214 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| Postbaccalaureate Research Education Program (PREP)(R25 - Independent Clinical Trial Not Allowed) Apply for PAR 22 220 Funding Number: PAR 22 220 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| Data-Driven Tools to Accelerate the Clinical Translation of Novel Dental, Oral, and Craniofacial Biomaterials (R42 Fast-Track - Clinical Trial Not Allowed) Apply for RFA DE 23 007 Funding Number: RFA DE 23 007 Agency: National Institutes of Health Category: Health Funding Amount: $750,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 22 213", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.