Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional) | PAR 22 213

Opportunity Information: Apply for PAR 22 213

The NIH funding opportunity PAR 22-213, titled "Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional)," supports large, coordinated aging research programs built around a single, clearly defined scientific question or theme relevant to aging. The intent is to fund projects that are too large or too interdependent to be handled well as a set of separate grants, and that genuinely require multiple integrated components working together. Applications are expected to describe a complex, multi-part research effort where the pieces are scientifically linked and collectively designed to answer a central question in aging research, rather than a loose collection of independent studies.

This opportunity uses the U19 mechanism, which is a cooperative agreement. In practice, that means the NIH is not simply providing funds and stepping back; instead, the funded team should anticipate ongoing scientific or programmatic involvement from the NIH during the life of the award. The FOA is also labeled "Clinical Trial Optional," meaning applicants may include a clinical trial component if it is appropriate for the overall integrated project, but a clinical trial is not required. The emphasis is on tightly connected, multidisciplinary work that benefits from coordination, shared resources, and an overall management structure that keeps the components aligned.

Projects funded under this FOA will typically involve multidisciplinary investigator teams, either within a single institution or across a consortium of institutions. The structure is meant for research that needs multiple interacting parts, such as different projects, cores, shared methods, coordinated data approaches, or other components that depend on each other to succeed. Reviewers will generally expect the application to make a strong case that integration is essential, explaining how the different parts inform one another, how coordination will be handled, and how the overall design improves scientific payoff compared with smaller or stand-alone studies.

Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including both 501(c)(3) and non-501(c)(3) nonprofits) other than institutions of higher education; for-profit organizations other than small businesses; small businesses; public housing authorities/Indian housing authorities; and Native American tribal governments (federally recognized) as well as Native American tribal organizations that are not federally recognized tribal governments. The FOA also explicitly highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal government agencies, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions.

At the same time, the FOA places clear limits on foreign involvement. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as the applicant organization. In addition, non-domestic components of U.S. organizations are not eligible to apply. However, foreign components are allowed as defined in the NIH Grants Policy Statement, which generally means a U.S. applicant can include certain types of foreign collaboration or subcomponents when they are well-justified and meet NIH policy requirements.

From an administrative standpoint, this is a discretionary funding opportunity under the health category, with assistance listing CFDA number 93.866, and it is administered by the National Institutes of Health. The FOA was created on 2022-07-07, and the listed original closing date is 2025-09-25. The source information provided does not specify an award ceiling or the expected number of awards, which typically means applicants should rely on the full FOA text and NIH guidance for budgeting expectations and any institute- or program-specific constraints.

Overall, the opportunity is best suited for applicants who can propose a cohesive, high-impact aging research program that demands strong integration across multiple research components, supported by a management and collaboration plan capable of handling the complexity of a cooperative agreement. The most competitive proposals will usually be the ones that make the integration feel necessary rather than optional, show how the team and infrastructure are set up to operate as one coordinated effort, and demonstrate a clear pathway to advancing aging-related science through the combined contributions of all components.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Complex Integrated Multi-Component Projects in Aging Research (U19 Clinical Trial Optional)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.866.
• This funding opportunity was created on 2022-07-07.
• Applicants must submit their applications by 2025-09-25. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 22 213

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