Opportunity Information: Apply for CDC RFA CK22 2203
The grant opportunity "Strengthening Healthcare Infection Prevention and Control and Improving Patient Safety in the United States" (CDC RFA CK22-2203) is a CDC cooperative agreement designed to close the infection prevention and control (IPC) gaps that became especially visible during the COVID-19 pandemic. At its core, the program aims to reduce the spread of infections in healthcare settings, protect patients and healthcare personnel, and improve the overall safety and quality of care. CDC is looking for practical, real-world ways to implement its evidence-based IPC guidance not only during routine operations, but also during emergencies when healthcare systems are under stress and normal processes can break down. The work is housed within HHS/CDC's National Center for Emerging and Zoonotic Infectious Diseases (NCEZID) and aligns with broader federal priorities around preventing infectious disease transmission in healthcare environments.
A central theme of the NOFO is implementation: taking what is known from guidance and translating it into consistent, workable practice across many types of healthcare settings. The opportunity emphasizes identifying common IPC failure points (for example, breakdowns in protocols, inconsistent work processes, unclear instructions, or training that does not translate into daily behavior) and then building solutions that make correct IPC practice easier to follow and harder to miss. CDC also signals a strong interest in partners that are not already deeply engaged through existing CDC IPC programs, with the goal of broadening the network of organizations contributing to IPC improvement. This includes building or expanding partnerships with academic institutions, healthcare systems, professional organizations, and other groups that can bring specialized expertise, infrastructure, technology, and access to healthcare personnel populations.
The NOFO is structured around two major components. Component 1 focuses on strengthening IPC to improve patient and worker safety by changing the conditions in which care is delivered, not just the knowledge of staff. Activities under this component can include improving healthcare facility structure, design, and organization; optimizing the design and safe use of materials and equipment across different healthcare environments; and strengthening IPC work processes, procedures, and everyday practices. It also encourages efforts that standardize and reinforce practices that keep the healthcare environment safe, including attention to air, water, and surfaces, and work that improves IPC preparedness so facilities can maintain strong infection control when facing outbreaks or other emergencies. In practical terms, this component is about designing safer systems: clearer workflows, better physical and functional layout, and processes that reduce the chance that busy staff will inadvertently skip critical infection control steps.
Component 2 concentrates on the people side of IPC: training, education, and competency assessment. CDC is seeking innovative, effective approaches that improve how healthcare personnel learn IPC and how their skills are evaluated in ways that reflect real job conditions. This includes developing and testing training methods that actually change practice, as well as implementing improved or entirely new ways to assess competency so facilities and health departments can have more confidence that staff can perform IPC tasks correctly. Component 2 also extends beyond healthcare facilities to strengthen the capability of the public health workforce to support healthcare IPC and to prevent and respond to healthcare-associated infections (HAI) and antibiotic resistance (AR). This links the training and competency work to broader health system readiness, outbreak response capacity, and coordinated action between healthcare and public health partners.
The NOFO also explicitly connects to Project Firstline, the CDC-led initiative launched in 2020 to strengthen IPC practice and training through a national collaborative of healthcare, public health, and academic partners. Funding under this opportunity supports Project Firstline implementation by improving the design and effectiveness of IPC training and education for healthcare personnel. The intention is not only to create materials, but to improve how training is delivered, how well it works for different roles and settings, and how reliably it leads to correct IPC behaviors on the job. A key expectation is that funded efforts will help translate guidance and recommendations into practices that are feasible in diverse healthcare settings, rather than assuming that one approach fits all.
Equity is built into the rationale and expected impact. CDC highlights the need to reach a broad range of healthcare personnel and settings, including those serving populations at higher risk for poor outcomes. By widening the partner base and investing in approaches that work across different facility types and workforce groups, the program is meant to address disparities in IPC training access, competencies, and implementation. In other words, the intent is to strengthen infection control everywhere, not just in large, well-resourced institutions.
From an administrative standpoint, this is a discretionary funding opportunity using a cooperative agreement mechanism, meaning CDC expects to have substantial involvement with recipients compared with a standard grant. The CFDA/Assistance Listing number is 93.421. The opportunity anticipated about 12 awards (as listed in the source), and the eligible applicant pool is broad: state, county, and local governments; tribal governments and tribal organizations; public housing authorities; K-12 independent school districts; public and private institutions of higher education; nonprofits with or without 501(c)(3) status; for-profit organizations (including other than small businesses); and small businesses, with additional eligibility details referenced in the full notice. Applicants are expected to bring capabilities and partnerships strong enough to meaningfully improve IPC practice, and proposals may complement existing CDC-funded work but must not duplicate activities already supported through other CDC mechanisms.
Key dates included in the listing indicate the NOFO was created December 3, 2021, with an original application due date of March 15, 2022 (submitted electronically by 11:59 pm ET). Overall, the opportunity is aimed at moving beyond awareness and written policy to measurable improvement in how infection prevention and control is carried out day to day, combining systems-level changes in healthcare environments with stronger training and competency assessment for the workforce that has to execute IPC correctly under real-world conditions.Apply for CDC RFA CK22 2203
- The Department of Health and Human Services, Centers for Disease Control - NCEZID in the health sector is offering a public funding opportunity titled "Strengthening Healthcare Infection Prevention and Control and Improving Patient Safety in the United States" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.421.
- This funding opportunity was created on Dec 03, 2021.
- Applicants must submit their applications by Mar 15, 2022 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 12 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification), Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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